Nizoral 200 Mg 10 Tablets ingredient Ketoconazole View larger

Nizoral 200 Mg 10 Tablets ingredient Ketoconazole

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Nizoral 200 Mg 10 Tablets ingredient Ketoconazole

It is taken by mouth.
• Active ingredient: Ketoconazole.
Each NIZORAL Tablet contains 200 milligrams of ketoconazole.

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Auxiliary ingredients: corn starch, lactose, polyvinyl chloride, microcrystalline cellulose, colloid anhydride silica and magnesium stearate.
You should read this USE INSTRUCTION carefully before you start using this medicine, because it contains important information for you.

• Keep these instructions for use. You can need to read again.
•If you have other questions, please talk your doctor or pharmacist.
• This medication has been prescribed for you personally, do not give it to others.
• Tell your doctor if you go to a doctor or hospital when using this medicine.
• We sleep exactly as written in this instruction. Do not use high or low doses other than the recommended dose for the medication.

In this Instructions for Use:
1. What is NIZORAL and what is it used for?
2. Things to watch out for before using NIZORAL
3. How to use NIZORAL
4. What are the possible side effects?
5. NIZORAL hiding
Their headlines are in place.

1. What is NIZORAL and what is it used for?
• NIZORAL The tablet is shaped like a tablet with white, round, flat, sloping edges, notched and with "JANSSEN" on one side and "K / 200" on the other side.
NIZORAL Tablet is presented to the market in blister packages containing 10 tablets.
• ketoconazole, the active ingredient of NIZORAL, belongs to a group of drugs called imidazole-derived systemic antimycotics.
Ketoconazole disrupts the structure of the fungal cell wall, leading to the death of the fungal cell.
Fungi are microorganisms commonly found in the environment we live in. They can cause fungal infections in a wide variety of species by being placed on the body surface or internal organs. The indication of the resulting infectious disease can vary according to the region or organ found.

Nizoral is a medication for the treatment of fungal infections including skin fungus and yeast (eg Candida).
Used in the following situations:

- infections of the skin, hair and mucous membranes which can not be treated by direct application to the infected area;
- resistant vaginal infection;
- mouth, throat and stomach, intestines, other internal organs or infections in several organs at the same time.
Since ketaconazole has no good effect on the central nervous system, oral ketoconazole should not be used in the treatment of fungal meningitis.

2. Things to watch out for before using NIZORAL
YOU DO NOT USE NIZORAL in the following situations:


Do not use Nizoral when:
- if you have any liver problems;
- if you know you are overly sensitive.
Also, do not use Nizoral when you are:
- certain allergy medicines such as terfenadine, astemizole and mizolastine;
halofantrine, a drug used in the treatment of smoking;
levacetylmethadol (levometadil), a drug used in the management of severe pain or addiction;
- cisapride, a drug used in a number of digestive problems;
domperidone, which is a drug used for nausea, vomiting, and nausea associated with reflux gastrointestinal motility or reflux of the stomach acid to the food intake;
- certain drugs, such as simvastatin and lovastatin, that lower cholesterol;
- some sleeping pills, midazolam and triazolam;
- drugs for psychotic disorders, pimozide or sertindole;
- certain medications such as quinidine, dizopramide and dofetilide used in the treatment of irregular heart rhythm;

- certain medications such as angina (overwhelming chest pain) and bepridil, epleronone and nizoldipine used in the treatment of high blood pressure;
drugs called ergot alkaloids, which are used to control bleeding such as erythromycin, ergometrine (ergonovin), methylergometrine (methylergonovin), and to maintain uterine contraction after birth;
irinotecan, an anti-cancer agent;
- usually everolimus given after transplantation.

USE NIZORAL ATTENTION:
If;

- If symptoms such as loss of appetite, nausea, vomiting, fatigue, yellowing of the eyes and / or skin, abdominal pain, darkening of the urine color occur, stop taking the medicine and consult your doctor immediately. These may be an indication of hepatitis (hepatitis).
Ketoconazole is a toxic substance on the liver. Liver function should be monitored before treatment, and should be monitored at regular and frequent intervals during treatment. In very rare cases, serious liver poisoning has occurred due to the use of ketoconazole orally in the oral cavity or requiring liver transplantation. In some of these patients, there is no significant risk factor for liver disease. The incidents were reported in the first month of treatment, some of them in the first week.
- If you are taking antacid medications for your stomach complaints, we will take them 2 hours after taking NIZORAL. Because these drugs reduce the absorption of ketoconazole.
- If you are taking medications that suppress acid excretion (such as H2 antagonists, proton pump inhibitors) for your stomach complaints, take NIZORAL with acid enhancers (cola, soda, etc.). Because these drugs reduce the absorption of ketoconazole.
NIZORAL has the potential for clinically significant drug interactions; Use with caution in conjunction with such medicines (see section on use with other medicines).
Adrenal function should be monitored in patients undergoing long-term stress (patients undergoing major surgery, intensive care, etc.) in patients with insufficiency or limited function of the adrenal glands.
Please consult your doctor if these warnings are valid for you, even at any time in the past.
NIZORAL's use with food and drink:
NIZORAL should be eaten with some liquid with the meal.

Pregnancy
Consult your doctor or pharmacist before using this medication.
Use of NIZORAL in pregnancy should be avoided except in very compulsory situations. If you are pregnant, your doctor will carefully evaluate the situation and decide whether to use NIZORAL.
If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.
Breast-feeding
Consult your doctor or pharmacist before using this medication.
NIZORAL should be avoided in mothers suckling babies.

Vehicle and machine use
There is no effect on the use of the vehicle and the machine.
Important information about some of the ancillary substances contained in NIZORAL
NIZORAL Tablet contains lactose. If you have previously been told by your doctor that you are intolerant to certain sugars, you should consult your doctor before taking this medicinal product.

Use with other medicines
Nizoral should have enough acid in the stomach to ensure that it is properly absorbed by your body. For this reason, drugs that neutralize gastric acid for at least 2 hours after Nizoral should not be taken. For the same reason, if you are taking medicines that stop the production of stomach acid, you should buy Nizoral with a drink that contains the cola.
- Do not forget to tell your doctor or your pharmacist what medicines you use. Especially some drugs should not be taken in the same period and adaptation for other drugs should be done.

Examples of medicines you should definitely not take while taking nizoral:
certain allergy medicines such as terfenadine, astemizole and mizolastine;
halofantrine, a drug used in the treatment of smoking;
levacetylmethadol (levometadil), a drug used in the management of severe pain or addiction;
- cisapride, a drug used to fight digestive problems;
domperidone, which is a drug used for nausea, vomiting, and nausea associated with reflux gastrointestinal motility or reflux of the stomach acid to the food intake;
some medications, such as simvastatin and lovastatin, which lower cholesterol;
- some sleeping pills, midazolam and triazolam;
drugs used for psychotic disorders, pimozide or sertindole;
some medications such as quinidine, disopyramide and dofetilide used in the treatment of uneven cardiac rhythm;
some medications, such as bepiridil, epleronone and nisoldipine, used in the treatment of angina (overwhelming chest pain) or high blood pressure;
drugs called ergot alkaloids, which are used to control bleeding such as erythromycin, ergometrine (ergonovin), methylergometrine (methylergonovin), and to maintain uterine contraction after birth;
irinotecan, an anti-cancer agent;
- usually everolimus given after transplantation.
Nizoral or other drug dosage changes may be required for combination with other drugs. For example:

- certain medications used in the treatment of tuberculosis (eg rifampicin, rifabutin and isoniazid) and epilepsy (eg carbamazepine and phenytoin);
- some products affecting the heart and blood vessels (digoxin and calcium channel blocker verapamil);
- drugs that slow blood clotting;
- methylprednisolone, budesonide, fluticasone and dexamethasone, by injection or inhalation for oral inflammation, asthma and allergies, or oral medicines;
- cyclosporin, tacrolimus and rapamycin (= sirolimus) usually given after transplantation;
- some HIV protease inhibitors;
nevirapine, an HIV non-nucleoside reverse transcriptase inhibitor;
- some drugs used in the treatment of cancer such as bulussan, docetaxel, erlotinib and imatinib;
- some medications, such as buspiron, alprazolam and brotisolam, used for anxiety or to help sleep (sedation);
- sildenafil for erectile dysfunction;
- trimetrexate used in the treatment of a particular pneumoniae;
ebastine used for allergies;
atorvastatin used to lower cholesterol;
- reboxetine used in the treatment of depression;
some painkillers such as fentanyl and alfentanil;
cilostazol which is used to help stabilization;
- electretan used in migraine headaches;
repaglinide used immediately;
tolterodine and solifenacin, which are used to help control the need for frequent urination;
- quetiapine used in psychiatric disorders.

Very rare cases, when used with alcohol, have been reported to have disulfiram-like reaction to the character characterized by flushing, rash, fluid accumulation in the body, nausea and headache in the face and neck. For this reason, it is recommended that you do not drink alcohol during Nizoral treatment.
If you are currently using or have used a prescription or over-the-counter medication, please tell your doctor or pharmacist about them.

3. How to use NIZORAL
Instructions for proper use and dose / application frequency:
Always take NIZORAL exactly as your doctor tells you. If you are unsure, consult your doctor or pharmacist.

adults
1 tablet (= 200 mg) once a day with food. If this dose is not sufficient, the dose can be increased to 2 tablets taken once a day (= 400 mg).
Adults with vaginal candidiasis: 2 tablets once daily (= 400 mg) with food.

children
- Children between 15 and 30 pounds: Half a tablet (= 100 mg) taken once a day with meals
- For children over 30 kg: The same dose as adults.

Application path and method:
The tablets should be swallowed with some liquid.
Application time:
If your doctor suggests otherwise, you should use your medicine for the following periods according to the diseases:

- Vaginal candidiasis: 5 days
- Skin infections caused by dermatophytes: Approximately 4 weeks
- Pityriasis versicolor: 10 days
- mouth and skin infections caused by candidiasis: 2-3 weeks
- Hair infections: 1-2 months
- Paracoccidioidomycosis, histoplasmosis, coccidioidomycosis: The overall duration of treatment is 6 months.

In all these conditions, treatment should continue uninterrupted until clinical indications or laboratory tests show that the fungal infection has improved. An inadequate treatment period can lead to recurrent active infection. If liver irritation, such as loss of appetite, nausea, vomiting, weakness, yellowing of the eyes and / or skin, abdominal pain or dark urine, occurs, do not continue treatment further and contact your doctor immediately. In such a case, your doctor will do some blood tests showing liver function.

Different age groups:
Use in children: NIZORAL is not recommended for use in very young children, as the data on the use of NIZORAL in children under 15 kg are limited.

Special use cases:
Hepatic insufficiency: It should not be used in patients with hepatic impairment.
If you have an impression that NIZORAL's effect is too strong or too weak, talk to your doctor or pharmacist.
If you use more NIZORAL than you need
NIZORAL 'If you have used too much, talk to a doctor or pharmacist.

It is important to follow the dose prescribed by your doctor. If you accidentally get more tablets, do not delay what you will do to your doctor or consult your nearest hospital emergency department.

If you forget to use NIZORAL

If you forget to take your medicine, you will not remember the remembrance in the same day. If you do not take your tablet on the same day, take your normal dose the next day. Do not take two doses on the same day.
Do not take double doses to compensate for forgotten doses.
If you have any other questions about the use of this medicine, we do not ask your doctor.

4. What are the possible side effects?
As with all medicines, there may be side effects in people sensitive to substances in the NIZORAL content.

If you have any of the following, stop using NIZORAL and report it to your doctor or contact your nearest hospital emergency department:
- Severe allergic and anaphylactic reactions such as swelling in the face, mouth, and throat (angioneurotic edema), severe drop in blood pressure with shortness of breath;
These are all very serious side effects.
If you have them, then you have a serious allergy against NIZORAL. You may need to be admitted to an emergency medical intervention or hospital.
All of these very serious side effects are very rare.
If you notice any of the following, tell your doctor immediately or contact the emergency department of your nearest hospital:
- Morning, bruises and beryls at various parts of the body (reduction of blood platelets may be indicated),
- Sudden nausea / vomiting, impaired vision (intracranial pressure increase may be indicated),
- Loss of appetite, nausea, vomiting, weakness, yellowing of the eyes and / or skin, abdominal pain or dark urine (liver inflammation indication),
All these are serious side effects. Immediate medical attention may be required.
Serious side effects are very rare.
If you notice any of the following, tell your doctor:
The following side effects have been widely reported (less than 1 in 10 people, affecting more than 1 in 100 people): Nausea / vomiting, abdominal pain, itching.
The following side effects have been reported uncommonly (less than 1 in 100 people, affecting more than 1 in 1000 people): headache, dizziness, somnolence, diarrhea, rash.

The following side effects have been reported very infrequently (affecting less than 1 in 10,000 people): Allergic conditions, suprarenal insufficiency, tingling / pinning, lightning, indigestion, liver disorder, hives, hair loss, light sensitivity, erectile dysfunction in men , breast enlargement in males, deterioration of moonlight hemorrhage, reduction in sperm count (at doses higher than the recommended daily treatment doses of 200-400 mg / day).

These are the minor side effects of NIZORAL.
If you notice any side effects not mentioned in these instructions for use, inform your doctor or pharmacist.

5. Keeping NIZORAL
Keep NIZORAL in places and in its packaging where children can not, can not reach.
Store at room temperature below 30 oC and in a dry place.
Use in accordance with expiration dates.
Do not use NIZORAL after the expiration date on the packaging.
Do not use NIZORAL unless you notice any defects in the product and / or packaging.