Adrenaline (Epipen, Epinephrine) 10 Vial

It is applied into muscle, vein, heart, trachea or subcutaneously.

Each 1 ml ampoule;

Active ingredient
1 mg of adrenaline,

Excipients
Contains sodium chloride, sodium metabisulfite (E223) and water for injection.
2.What is ADRENALINE and what is it used for?

ADRENALINE is presented in boxes of 10 and 100 ampoules containing 1 mg of adrenaline in one ampoule. Ampoules contain a sterile, clear, colorless solution. Adrenaline is used in the following situations:

Cardiac arrest and cardiopulmonary reanimation

If artificial respiration and open or closed heart compression do not benefit, ADRENALINE can be administered intravenously, into the heart or trachea after intravenous sodium bicarbonate is given.

Anaphylactic shock (hypersensitivity reaction with low blood pressure) and acute (sudden onset) allergic reactions

It is used as a physiological antagonist of histamine against angioedema (non-itching and reddening of the skin as a result of allergies), drug and serum reactions, insect bites and other allergens. If there is shock, it is not administered subcutaneously. In addition, the patient in shock should be given an intravenous H1 receptor antagonist (chlorpheniramine).

• Acute (sudden) asthma attacks and bronchospasm (contraction of the bronchi and bronchi)

It is given under the skin.

• Stopping capillary (superficial) bleeding in the skin and mucous membranes. It is given locally as a solution.

• Extending the duration of action of local anesthetics (drugs that provide regional anesthesia) It is added as a vasoconstrictor (vasoconstrictor) by dentists.
3. How to use ADRENALINE?

Since ADRENALIN will be administered by your doctor or a healthcare professional, the following section is for your physician or healthcare personnel.
Instructions for proper use and dose / frequency of administration

Dosage in cases of bronchospasm and hypersensitivity reactions:

The usual starting dose for adults in acute anaphylaxis, painful asthma and allergic reactions is 0.10.5 mg (0.1-0.5 ml) of ADRENALINE, and it is administered subcutaneously or intramuscularly. If the cause of the allergy is a drug that is administered subcutaneously or intramuscularly, ADRENALINE injection can be applied to different places to delay and reduce absorption. Initial doses of ADRENALIN should be small, these can be increased if necessary. However, the dose given at one time should not exceed 1 mg.

In anaphylactic shock, subcutaneous doses can be repeated at 10-15 minute intervals. In painful asthma crises, subcutaneous doses can be repeated at intervals of 20 minutes to 4 hours, depending on the response of the patient.

In chronic obstructive pulmonary disease, 0.3 mg (0.3 ml) of adrenaline is given 3 times 20 minutes apart, and this scheme can be repeated every 2 hours.

In severe anaphylactic shock, the intravenous route should be used to allow the drug to enter the circulation. For this, 0.1-0.2 mg (0.1-0.2 ml) of ADRENALINE is diluted with 8-10 cream water for injection and given slowly by intravenous injection. If necessary, this can be repeated every 5-15 minutes.

Dosage in case of cardiac arrest:

For heart reanimation in adults, 0.5-1 mg (0.5-1 ml) of ADRENALINE is diluted and injected intravenously or intracardiac. Intravenous route is preferred in order not to prevent heart massage. 1-2 mg (1-2 ml) of ADRENALIN is added to 10 ml of sterile distilled water and instilled into the trachea through the endotracheal tube or 0.3 mg (0.3 ml) of ADRENALINE is administered subcutaneously after the first intravenous injection or as an intravenous infusion of 1-4 μg / dl <is given with speed.

Other forms of administration and dosages:

Adrenaline solutions at a concentration of 1: 50.000 (0.002%) - 1: 1.000 (0.1%) are applied to the skin, mucosa and tissue surfaces as wet dressing or spray locally. Adrenaline is added to local anesthetic solutions at a ratio of 1: 500.000-1: 50.000. The most commonly used concentration is 1: 200,000.

Application route and method

ADRENALINE is preferably injected subcutaneously. It can also be done intramuscularly, but the gluteus muscles should not be used (Anaerobe microorganisms can colonize in the skin of this area and the vasoconstrictor effect of ADRENALIN can accelerate the formation of Clostridium welchii infection by causing hypoxia.).

In emergencies, ADRENALINE can be diluted and given as a very slow intravenous injection. In case of cardiac arrest, diluted adrenaline solution can be given by intracardiac injection or endotracheal instillation. Heart massage should also be applied when injected into the heart. In this way, it is ensured that the drug is included in the coronary circulation. Adrenaline can be given to an aerosol, vaporizer, IPPB device as oral inhalation.

Adrenaline solutions used for this purpose are more concentrated and injecting them systemically should be avoided. ADRENALINE can be diluted and applied locally to skin, mucosa and tissue surfaces. Wet dressing or spray forms are used for this.

Adrenaline dose is expressed by the amount of adrenaline in adrenaline salts.

Different age groups

Use in children

Dosage in cases of bronchospasm and hypersensitivity reactions: