Beloc Zok (Metoprolol) 20 Tablets

How to use the 3.BELOC® ZOK

Instructions for appropriate use and dose / frequency of administration: Always take BELOC® ZOK as prescribed by your doctor. If you are not sure, consult your doctor or pharmacist.

BELOC® The ZOK-controlled release film tablet is an all-day medication and should be taken daily.

Application route and method: BELOC® ZOK is taken orally. Tablets can be taken by dividing. Swallow the tablets together with at least half a glass of water. Do not crush and chew the tablets.

Different age groups: Use in children: Not enough data to recommend the use of BELOC® ZOK in children. Use in the elderly: Initially, the lowest possible dose should be used.

Special Use Cases: Renal insufficiency: Dose adjustment is not required in patients with renal insufficiency.

Liver failure: Your doctor will decide if dose adjustment is necessary in patients with severe hepatic impairment.

Talk to your doctor or pharmacist if you have an impression that BELOC® ZOK is too strong or too weak.

If you use more BELOC® ZOK than you should use: If the dose you receive is high, you may experience the following symptoms: Heart beat irregularity or decline, shortness of breath, swelling of the feet, feeling heart beat in the chest, dizziness, fatigue, chest pain, skin cooling, low pulse, mental disorder, restlessness, cardiac arrest, constriction of the airways, partial or complete loss of consciousness / coma, nausea, vomiting and bruising.

For this reason, it is important that you do not take a high dose and that you use the doses prescribed by your doctor.

The above symptoms may worsen if you use quinidine and sleep medications (barbiturates), other blood pressure lowering drugs and alcohol with metoprolol.

Symptoms of exposure to a high dose occur 20 minutes to 2 hours after taking your medication.

If any of the above symptoms occur, contact your doctor or hospital immediately.

Talk to a doctor or pharmacist if you have used more than the BELOC® ZOK.

If you forget to use BELOC® ZOK, do not take a double dose to compensate for the missed doses.

BELOC® Side effects that may occur after treatment with ZOK Do not stop the BELOC® ZOK treatment without talking to your doctor, because if you stop taking the medication suddenly, some symptoms of the disease (eg palpitation and chest pain) may get worse.

4. What are the possible side effects? As with all medications, BELOC® ZOK may have side effects in people who are sensitive to the substances contained in its contents.

Side effects are listed as follows;

Very common: It can be seen in at least one of 10 patients. Common: Less than one in 10 patients, but more than one in 100 patients. Uncommon: Less than one in 100 patients, but more than one in 1000 patients. Rare: Less than one in 1000 patients. Very rare: less than one in 10,000 patients. Unknown: Unable to predict from available data.

Common: Headache, dizziness, dizziness, decrease in heart rate, palpitations, coldness in hands and feet, abdominal pain, nausea, vomiting, diarrhea, constipation, fatigue

Uncommon: Depression, concentration disorders, drowsiness or insomnia, nightmares, tingling and drowsiness, worsening of heart failure symptoms, significant decrease in blood pressure during heart attack (cardiogenic shock), chest pain, heart block, shortness of breath, feeling of stenosis in airways, gaining weight

. nervousness, restlessness (anxiety), sexual problems including impotence, memory difficulty, confusion, vision, visual disturbances, dryness in the eyes, redness and / or irritation, tinnitus, heart conduction disturbances in the ECG, irregular heartbeat, swelling (edema) ), fainting, taste disorder, liver problems ( liver function test anomalies), hypersensitivity to the skin (allergic) reactions, worsening of psoriasis, sensitivity to light, reversible sexual reluctance, excessive sweating, hair loss

Very sparse: Forgetfulness / memory weakness

Unknown: Eye inflammation-like symptoms In the patients with blood loss due to discontinuation or death of the tissue (gangrene), colds, dry mouth, inflammation of the liver (hepatitis), joint pain, muscle cramps

If you encounter any side effects mentioned in these instructions for use to inform your doctor or pharmacist.

5. Storage of BELOC® ZOK Store the BELOC® ZOK in a

place where children cannot and cannot reach them.

BELOC® ZOK should be stored at room temperature below 25 ° C.

Use in accordance with expiration dates.

Do not use BELOC® ZOK after the expiration date in its packaging.

The first two digits on the expiration date show the last four digits years. The expiry date refers to the last day of that month.

Registration holder: AstraZeneca İlaç San. and Tic. Ltd. Ltd. Şti Buyukdere Cad. Yapı Kredi Plaza B Block Floor 4 Levent - İstanbul

Production location: AstraZeneca AB, Södertalje, SWEDEN

These instructions for use are approved on 05.01.2015.

USE BELOC® ZOK CAUTION:If you have

•intermittentyou have impaired blood circulation,

, if• You have advanced renal failure,

clumping• You have chest pain caused by self-developing heart cramps called Prinzmental chest pain,

• Asthma, or airIf you

•have severe acute illness (metabolic acidosis) due to a high amount of acidic substances in the body,

• Tell your doctor that you are using BELOC® ZOK if you are going to be given general anesthetic medication or if you are going to be operated by your dentist.

Please consult your doctor if these warnings are valid for you, even at any time in the past.

Using the BELOC® ZOK with food and drink You can get the BELOC® ZOK on or on a full stomach.

Pregnancy Consult your doctor or pharmacist before using the medicine.

If you are pregnant or intend to become pregnant, tell your doctor before using the medicine.

Do not use BELOC® ZOK during pregnancy unless your doctor tells you otherwise.

Active substance metoprolol may cause heart rate in your baby.

If you discover that you are pregnant during your treatment, consult your doctor or pharmacist immediately.

Breastfeeding Consult your doctor or pharmacist before using the medicine.

If you are breastfeeding, do not use BELOC® ZOK unless necessary. The amount of metoprolol that the infant takes with the mother's milk is negligible for the beta blockage effect as long as the mother uses metoprolol in normal therapeutic doses. However, while breastfeeding, babies should be monitored for beta blockage symptoms.

Use of tools and machines BELOC® may cause deterioration of ZOK responses. During the use of this medicine, dizziness and fatigue can be observed, so do not use tools and machinery.

Important information on certain excipients contained in the BELOC® ZOK contains BELOC® ZOK. This should be considered for patients with a controlled sodium diet.

Use with other drugs Some drugs may be affected by BELOC ZOK therapy and / or may affect treatment. These;

• Propafenone, amiodarone, quinidine, verapamil, diltiazem, clonidine, disopramide and hydralazine, digital preparations / digoxin (drugs used in cardiovascular diseases), Clonidine and BELOC® ZOK at the same time and clonidine treatment should be terminated, You must cut a few days before clonidine. Refer to the section ile Effects that may occur when treatment with BELOC® ZOK is terminated abil regarding the discontinuation of BELOC® ZOK.

• Barbituric acid derivatives (drugs used for epilepsy),

• Medications for inflammation (eg, indomethacin and celecoxib),

• Adrenaline (a drug used for acute shock and severe allergic reactions),

• Phenylpropanolamine (swelling in the nasal tissues)a drug used for

•allergic conditions

• rifampicin (an antibiotic used in different diseases, especially tuberculosis);

• other beta-blockers (eg eye); drops),

• MAO inhibitors (drugs used in depression and Parkinson's disease)

• inhalation (by inhalation), anesthetics (drugs used for anesthesia)

• Anti-depressants (paroxetine, fluoxetine and sertraline),

• lowering high blood pressure drugs,

• Calcium channel inhibitor, treatment of diseases of the cardiovascular system drugs (Dihydropridine derivatives),

• Mood regulators (tricyclic antidepressants),

• Medications used to correct psychiatric disorders (phenothiazines),

• Cimetidine (medication that reduces acid production from the stomach),

• If you are taking oral antidiabetic medication, your doctor may make dosage adjustments.

Please inform your doctor or pharmacist if you are currently using any prescription or non-prescription medication or if you have recently used it.