Eliquis (Apixaban) 56 Tablets

USAGE INSTRUCTIONS

Please read this INSTRUCTIONS carefully before using this medicine, as it contains important information for you.

- Keep these instructions for use. You can need to read again. - If you have any additional questions, please consult your doctor or pharmacist. - This drug has been prescribed for you personally, please do not give to others. - Whenthis medicineyou are taking this medicineyou go to a doctor or hospital

using, tell your doctor thatwhen. - Obey exactly what is written in this instruction. Doother than the recommended dose for the

not use high or low dosesdrug.

In these operating instructions:

1. What is ELIQUIS and what is it used for? 2. Things to consider before using ELIQUIS. 3. How to use ELIQUIS 4. What are the possible side effects? 5. ELIQUIS storage of tablets is included in the Headings.

1. What is ELIQUIS and what is it used for?

Film-coated tablets are yellow, rounded, with “893” on one side and ında 2 1 bir2 ”on the other side. 10, 20 and 60 film-coated tablets are sold in a cardboard box containing blisters.

ELIQUIS contains apiksaban as the active ingredient and belongs to a group of drugs called anticoagulants. This drug prevents the formation of blood clots by blocking the factor Xa, an important substance that provides blood clotting.

The possibility of developing blood clots in your leg veins may be increased after having an operation on the hips or knees. This may cause painful or painless swelling in your legs. If the blood clot moves from your leg to your lungs, this clot can block blood flow and cause shortness of breath without chest pain or chest pain. This condition (pulmonary embolism) can be life-threatening and requires immediate medical attention.

ELIQUIS is especially used in adults to help prevent blood clot formation after hip or knee prosthetic surgeries.

2. Things to consider before using ELIQUIS DO NOT use ELIQUIS in the following cases: -have allergies to any substance in the composition of Apiksaban or ELIQUIS

If you- if you have excessive bleeding - if you have liver disease causing hepatic hemorrhage (hepatic coagulopathy),

ELIQUIS USE CAREFULLY in the following casesRisk of increased bleeding, such as:

-- Bleeding disorders; diseases that cause lower platelet activity - active or new ulcer in the stomach or intestine - heart infection (bacterial endocarditis) - recently bleeding in the brain (hemorrhagic stroke) - very high blood pressure, which can not be controlled by medical treatment - related to the brain, spinal cord or eye a recent operation - severe kidney disease or dialysis - history of a liver problem or liver problem

Your doctor will test your liver function before you use ELIQUIS, and this medication will be used with caution in patients with signs of changes in liver function. - a tube (catheter) placed in your spinal cord, or an injection into your spinal cord

(for anesthesia or pain relief); your doctor will tell you to take ELIQUIS 5 hours or more after the catheter has been removed.

Please consult with your doctor if these warnings are valid for you, even at any time in the past.

ELIQUIS is not recommended in children and adolescents and in adolescents under 18 years of age.

Use of ELIQUIS with food and drink ELIQUIS can be taken with food or alone.

Pregnancy Consult your doctor or pharmacist before using the medicine.

The effects of ELIQUIS on pregnancy and unborn children are unknown. You should not use ELIQUIS if you are pregnant.

If you discover that you are pregnant during your treatment, consult your doctor or pharmacist immediately.

Breastfeeding Consult your doctor or pharmacist before using the medicine. It is not known whether ELIQUIS passes into human milk.

Use of tools and machinery Whether or not ELIQUIS has an impact on the ability to drive and use machines is not shown.

Important information about some of the ingredients in the content of ELIQUIS ELIQUIS contains lactose (a kind of sugar). If you have been told by your doctor that you are intolerant of some sugars, contact your doctor before taking this medicinal product.

Use with other drugs Some drugs increase the effects of ELIQUIS while others reduce it. Your doctor will decide whether you can use ELIQUIS when taking these medications and how often you should be followed.

The following drugs may increase the effects of ELIQUIS and increase the likelihood of unwanted bleeding: - Some drugs used for fungal infections (eg ketoconazole, etc.) - Some antiviral drugs used for HIV / AIDS (eg ritonavir) - Other medications used to reduce blood clotting ( eg enoxaparin, etc.) - Anti-inflammatory or pain medications (eg aspirin or naproxen) - Drugs used for high blood pressure or heart problems (eg diltiazem)

The following drugs may reduce the effects of ELIQUIS on preventing blood clot formation: - Sara (epilepsy) or drugs used to prevent seizures (eg. phenytoin, etc.) - St. John's Wort (St. John's Wort: herbal supplement used for depression) - used to treat tuberculosis or other infections, drugs (eg. rifampicin)

If the prescription or you are currently using any non-prescription medication or Please inform your doctor or pharmacist about these if you used them.

How to use ELIQUIS

Instructions for proper use and dose / frequency of administration: Always take ELIQUIS as your doctor told you. If in doubt, you should consult your doctor or pharmacist.

The usual dose is 2.5 mg 2 times a day, for example, one tablet in the morning and one in the evening. Try to take the tablets at the same time each day to help you remember that you need to take the tablets.

You should take the first tablet within 12 to 24 hours after your surgery. As long as your doctor tells you to take this medicine, you should take one tablet twice a day every day.

Method and method of administration: ELIQUIS is taken orally. Swallow the tablet with water as a whole. Do not chew the tablet.

Duration of treatment If you have had major hip surgery, the tablets will take approximately 10 to 14 days if you have had major knee surgery for about 32 to 38 days.

Different age groups

Use in children: ELIQUIS is not recommended in children and adolescents under 18 years of age.

Use in the elderly: Dose adjustment is not required.

Specific conditions of use: Liver failure: ELIQUIS is not recommended in patients with severe liver disease.

Renal insufficiency: Dose adjustment is not necessary in patients with mild, moderate or severe renal insufficiency. ELIQUIS is not recommended in patients with advanced stage renal failure, where the outcome of Creatinine Clearance, a criterion for Kidney Function, is <15 ml / min, since there is no clinical experience.

Talk to your doctor or pharmacist if you have a view that the ELIQUIS effect is too strong or too weak.

If you have used more ELIQUIS than you should use: If you have used more than you should use from ELIQUIS, talk to a doctor or pharmacist. Take the medicine package with you. If you take more ELIQUIS than recommended, your risk of bleeding may increase. If bleeding occurs, surgery or blood transfusion is required.

If you forget to use ELIQUIS::

• Take the tablet as soon as you remember• take the

next ELIQUIS tablet in normal time

• then continue as usual.

If you are not sure what to do or if you have missed more than one dose, consult your doctor or pharmacist. Do not take double doses to compensate for the forgotten ELIQUIS dose.

Effects after ELIQUIS treatment is discontinued: Do not stop taking ELIQUIS without talking to your doctor because if you leave the treatment too early, the risk of developing blood clots may be higher. Ask your doctor or pharmacist if you have more questions about the use of this product.

4. What are the possible side effects? As with all medicines, people who are sensitive to substances found in ELIQUIS may have side effects.

If you experience any of the following symptoms after using this medicine, notify your doctor or pharmacist:

ELIQUIS may cause life-threatening bleeding. These bleedings may not be obvious and may result in anemia (weak blood cell count, which may create weakness or wilt).

The frequencies are defined as follows: - Very common: affects at least one of the 10 users - Common: one to one of the 100 users affects it - Not common: affects one to one of 1,000 users - Infrequently: one to one of its 10,000 users - Very rare: 10,000 users affects less

common side effects - fatigue or may be anemia causing pallor (anemia) - bleeding, eg .:

- blood in the urine (dye urine pink or red) - bruising and swelling - vaginal bleeding - Nausea

Uncommon side effects - platelet counts decreased in your blood ( Bleeding including:bleeding

- bruising and swelling,from the surgical wound / incision site, including blood or fluid leakage (wound secretion)

, hemorrhage after surgery - blood in the stomach, intestine or outside blood - blood in the urine in laboratory tests - Bleeding - low blood pressure where you may feel a weak or accelerated heartbeat - In blood tests:

- abnormal liver function, - increase in some liver enzymes - an increase in bilirub, which is the product of destruction of red blood cells, whichcause the skin and eyes to become yellow

may.

Rare side effects - Allergic reactions that can cause:face, lips, mouth, tongue and / or

swelling in thethroat and difficulty breathing. If you experience any of these symptoms, consult your physician immediately.

- Bleeding:

- in the muscles - in the eyes - bleeding in the gums and bleeding in the saliva when coughing - bleeding from the mouthmentioned in

If you encounter any side effects notthese instructions for use, please inform your doctor or pharmacist.

5. Storage of ELIQUIS tablets

Keep out of the reach of children and in the container. Store at room temperature below 25 ° C.

Use in accordance with the expiry date. Do not use ELIQUIS after the expiration date indicated on the box. The expiry date is the last day of the specified month.

Drugs should not be disposed of with waste water or household waste. Ask your pharmacist how to discard the drugs that are no longer needed. These measures will help protect the environment.