Glucotrol-XL (Glipizide) 20 Tablets

1. What is GLUCOTROL XL and what is it used for?

GLUCOTROL XL 10 mg Controlled Release Tablets are in a specially designed shell to allow slow release of the drug. The name li XL temsil in the name of the drug represents this feature. Each tablet contains 10 mg of glipizide as the active ingredient. Available in blister packages of 20 tablets

GLUCOTROL XL is an active ingredient in the group called glipizide sulfonylurea. Such drugs are drugs that are used against diabetes (to prevent diabetes by lowering blood sugar).

GLUCOTROL XL is used in addition to the diet in Type 2 diabetic patients where the appropriate diet is not successful.

Your body produces insulin to keep your blood sugar level at the proper level. In type 2 diabetes:

• Your body may not produce enough insulin

• Your body may not be able to use insulin

• Your blood sugar level may be too high

If your blood sugar level is not under control kidney damage, nerve damage, blindness, circulatory problems (blood movement in your body), foot, leg or Loss of other limbs can lead to serious medical problems such as high blood pressure, heart attack or stroke.

GLUCOTROL XL works mainly in the following ways:

• By helping yourrelease more of itsHelping your

bodyown insulin •body respond more to its own insulin

•by lowering the amount of glucose produced by the body

Even after you start taking GLUCOTROL XL, you will continue to fit into your diet and exercise programsshould

3. How to use GLUCOTROL XL?

Like other drugs used to lower blood sugar, the GLUCOTROL XL dose is also individually adjusted according to the patient's need. Therefore, it is important that you take your medicine as your doctor tells you. The following dose is for advice only.

Instructions for proper use and dose / frequency of administration: The recommended starting dose of GLUCOTROL XL is 1 tablet per day. GLUCOTROL XL tablets have 3 different doses (2.5 mg, 5 mg and 10 mg). Your doctor will prescribe you the appropriate dose.

Method and method of:

administration• Take your medication together with breakfast. Your tablet is designed for 24 hours. Therefore, you only need to use it once a day.

• Swallow GLUCOTROL XL tablets with sufficient amount of liquid (with a glass of water)

. • Take your tablet as a whole. Do not chew, split, or shred tablets. This causes too much drug release in your blood at one time by damaging the tablet.

• Do not change the dose or stop taking your tablets without talking to

Follow the advice ofdoctor about the food you eat

your doctor •your• Measure or measure your blood sugar regularly at the time that your doctor says

• In some patients, the effectiveness of reducing the blood glucose level to the desired level may decrease after a while. For this reason, go to the control of your doctor's time After all the drug is released, the empty tablet shell will be excreted in your body through the normal means of bowel movement. Don't worry if you see the empty tablet shell in your bowel (bowel movement).

It is important that you use the GLUCOTROL XL every day to help control your blood sugar level well. Depending on your blood glucose test results, your doctor may adjust your dose. If your blood sugar level is not under control, call your doctor. Do not change your dose without the advice of your doctor.

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While you are taking GLUCOTROL XL, continue your diet and exercise program. Have your blood and urine tests performed regularly to ensure that the GLUCOTROL XL works.

Different age groups: Use in children: Efficacy and safety in children has not been proven. Use in the elderly: In patients with elderly patients, patients with uneven, irregular calories, and so on, patients at risk should start at the lowest possible dose (2.5 mg daily) to reduce the risk of hypoglycemia (drop in blood sugar).

Special use cases: (kidney failure, liver failure, etc.) In patients with inadequate kidney or liver function, the lowest possible dose should be administered.

Patients receiving insulin In patients with a daily insulin requirement of 20 units or less, insulin can be discontinued and GLUCOTROL XL treatment can be started with normal doses. You should measure your own blood sugar during the insulin break. If you have abnormalities in these tests, contact your doctor immediately. In patients with a daily insulin requirement of more than 20 units, the insulin dose can be reduced by half and GLUCOTROL XL treatment can be started with normal doses. If you are using more than 40 units of insulin a day, your doctor may require you to be kept under control during the transition from insulin to GLUCOTROL XL treatment.

If you have an impression that the effect of GLUCOTROL XL is too strong or too weak, speak to your doctor or pharmacist.

If you have used more GLUCOTROL XL than you should use: If you have dizziness, tremor, irritability, sweating, drowsiness, palpitations, your blood sugar is too low. Eat something sweet and drink. If you are unconscious, please contact the emergency department of the nearest hospital. Talk to a doctor or pharmacist if you have used more than you should use from GLUCOTROL XL.

If you forget to use the GLUCOTROL XL: If you miss a dose, it is important to take your medicine when you remember it or when you feel fatigue, otherwise your blood sugar may rise too much and you can go into a coma (or lose consciousness). Do not take double doses to compensate for forgotten doses.

4. What are the possible side effects?

Like all medicines, GLUCOTROL XL may have side effects in people who are sensitive to the substances contained in its content.

Low blood sugar: GLUCOTROL XL can lower your blood sugar to dangerous levels (hypoglycemia). This can occur if you do not regularly monitor your diet and exercise, drink alcohol, become stressed, or become ill. This can also occur when the dose of GLUXOTROL XL is higher than is sufficient for you. Your doctor may need to adjust your dose. Do not adjust your dose yourself.

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Be sure to recognize your body symptoms when your blood sugar is low: These symptoms:

• Feel cold and damp

sweating

• Uncurrent• Drowsiness

• Fatigue

• Shivering

• Weakness

• Fasting

• Fast heartbeat

• Headache

• Blurred vision

• Speech disorder

• Lip or tingling in hands

If you notice any of these symptoms, immediately eat or drink something containing orange juice, honey, sugar, etc. If you are not feeling well or your blood sugar level does not increase, call your doctor. If you cannot reach your doctor, please contact the nearest hospital.

Other side effects: GLUCOTROL XL may cause other side effects in some people. However, the incidence of severe side effects with GLUCOTROL XL is very low. Other than the aforementioned low blood sugar symptoms, possible side effects are as follows:

• Angry feeling

• Diarrhea

•

Although not reported with the GLUCOTROL XL; a similar diabetes drug was associated with a high risk of heart attack. If you have risk factors for heart disease and are using GUCOTROL XL, see your doctor regularly.

Please inform your doctor or pharmacist if you experience any side effects not mentioned in these instructions.

5. Storage of

GLUCOTROL XL Keep GLUCOTROL XL in a place where the child cannot see, reach, and pack.

Store at room temperature below 25 ° C.

Do not use GLUCOTROL XL after the expiration date in the packaging.

License Holder: PFIZER Pharmaceuticals Ltd. Sti. 34347 Ortaköy .08Istanbul

Manufacturer: Pfizer Pharmaceuticals LLC, Puerto Rico

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These operating instructions were approved on 11.08.2011.

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