Triflucan (Fluconazole Diflucan) 7 Capsules

You should read this USE INSTRUCTION carefully before you start using this medicine, because it contains important information for you.

• Keep these instructions for use. You can need to read again.
• If you have other questions, please talk your doctor or pharmacist.
• This medicine has been prescribed for you personally, do not give it to others.
• When using this medicine, tell your doctor or doctor if you go to the hospital.
• We sleep exactly as written in this instruction. Do not use high or low doses other than the recommended dose for the medication.
In this Instructions for Use:

1.What is TRIFLUCAN and what is it used for?
2. Things to watch out for before using TRIFLUCAN
3. How to use TRIFLUCAN?
4. What are the possible side effects?
5. TRIFLUCAN hiding
Their headlines are in place.

1.What is TRIFLUCAN and what is it used for?
TRIFLUAN Pfizer logo and white, purple, opaque, number 0 capsule containing white powder printed with FLU-200 code.
TRIFLUCAN is one of a group of medicines called antifungals. The active substance is fluconazole.
TRIFLUCAN is used to treat infections caused by fungi, including yeast. In addition, yeast infection can also be used to prevent your cow. The most common cause of fungal infections is a yeast called Candida. one
This medicine can be given to you by your doctor to treat the following types of fungal infections.
• Mucosal canker, mouth or throat infection. Patients with normal or impaired immune function can be treated.
• Skin infections - eg. Foot fungus, fungal disease, itching.
• Internal (systemic) fungal infections due to:
• Candida which is found in the bloodstream, body organs (eg heart, lungs), membranes of the abdomen, a row of flat epithelial tissue covering the inside of the heart,
Cryptococcus, e.g. meningitis and other infections such as lung and skin
• The immune system is sufficient for the patients with developing systemic fungal diseases
You can also give TRIFLUCAN for you.
• Preventing a yeast infection (if your immune system is not functioning properly). In the case of cell-losing cancer due to malignant disease, the treatment of cancer or the treatment of cancer in the prevention of fungal infections in patients who prepare the ground for post-fungal infections.
• Preventing the return of an infection caused by Cryptococcus (in patients with AIDS)
Your doctor may begin your treatment before the results of your culture and other laboratory work are known. When the results are clear, the treatment will be regulated by your doctor as required.

2. Things to watch out for before using TRIFLUCAN
Do NOT use TRIFLUCAN in the following situations
If,
• If you have been hypersensitive to:
• to any component of TRIFLUCAN
• Other medicines you take to treat fungal infections.
Hypersensitivity may include itching, skin redness or difficulty in breathing.
• If you are taking antihistamine terfenadine or astemizole to treat allergies
• If you are taking cisapride for stomach spoilage
• If you are a schizophrenic patient and are taking antipsychotic medication pimozide
• If you are taking quinidine medication for heart rhythm disturbances.
TRIFLUCAN CAREFULLY USE THE FOLLOWING
If,
• If you have liver or kidney problems
• If your blood potassium, calcium, or magnesium levels are abnormal
• If you have a serious illness, especially AIDS and cancer

• If you are taking medication that potentially damages or irritates more than one simultaneous liver, and if there is underlying disease that will kill your liver tissue (hepatic necrosis). If your liver is damaged or irritated by fluconazole, it is recyclable. Your doctor will follow you in case of serious liver damage during treatment, if necessary, it may break your medicine.
• If rash skin reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome develop. Your doctor may discontinue your treatment if a hypersensitive state develops, such as a fluid-filled bubble-like disorder, or a spontaneous redness, usually on the hand, face and legs.
• If you use less than 400 mg of terfenadine per day
• Very severe response to allergy-causing substances in the body, if sudden hypersensitivity develops
• If you have electrolyte impairment
• If you are on other medications with fluconazole
• If you are taking concurrent medications that are not destroyed by CY3A4, an enzyme in the liver but known to prolong QT interval on ECG
Some azole group drugs, including fluconazole, showed a prolonged QT interval in the electrical activity record of the heart (ECG).
• If you have heart disease, including heart rhythm problems
• If there is a condition that can lead to severe arrhythmias and sudden deaths in the congenital or documented heart
• If you have an acute, subacute or chronic illness in your heart, especially when you have heart failure
• If your heart beats less than 60 minutes per minute (sinus bradycardia)
Please consult your doctor if these warnings apply to you, even at any time in the past.

Use of TRIFLUCAN pod with food and drink
Not available.

Pregnancy
Consult your doctor or pharmacist before using this medication.
Do not use TRIFLUCAN during pregnancy unless your doctor tells you the opposite.
If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.

Breast-feeding
Do not use TRIFLUCAN during pregnancy.
Consult your doctor or pharmacist before using this medication.
Vehicle and machine use
It should be noted that occasional dizziness or seizures may occur when using a vehicle or machine.

Important information about some of the auxiliary substances contained in TRIFLUCAN
This medicinal product contains lactose. If you are already told by your doctor that you are not able to withstand some of the sugars, you should consult your doctor before taking this medicinal product.

Use with other medicines
Please inform your doctor immediately, as they should not be taken with TRIFLUCAN.
• If you are taking antihistamine terfenadine or astemizole to treat allergies
• If you are taking cisapride for stomach spoilage
• If you are a schizophrenic patient and are taking antipsychotic medication pimozide
• If you are taking quinidine medication for heart rhythm disturbances.
The use of TRIFLUCAN with erythromycin, an antibiotic, is not recommended.
If you are taking any of the following medicines, tell your doctor. Some medicines that may interact with TRIFLUCAN include the use of precautions and dosing in conjunction with these medicinal products:
• Alfentanil used in anesthesia, fentanyl
• Amitriptyline and nortriptyline used in the treatment of depression
Amphotericin B for severe fungal diseases
• Warfarin (or similar medicines) for blood thinning to prevent blood clots.
• An antibiotic azithromycin
• Benzodiazepines, such as midazolam, triazolam, which help to sleep or worry, anxiety
• Calcium channel blockers such as nifedipine, isradipine, amlodipine and felodipine, which are used to lower blood pressure and are also used in some cardiac diseases
• Celecoxib used in the treatment of joint calcification
• Cyclophosphamide used in cancer treatment
Halofantrin used in the treatment of malaria
• HMG-CoA reductase inhibitors used for lipid disorders, metabolized with CYP3A4 such as atorvastatin and simvastatin or with CYP2C9 such as fluvastatin
• Losartan, a blood pressure lowering drug
• Metadone used in the treatment of heroin dependence
• Naproxen, lornoxicam, meloxicam, diclofenac pain, fever and inflammatory drugs
• Oral contraceptives, birth control pills
• Endogenous steroids
• Prednisone for acute organ rejection and antiinflammation
• Serinavir used in the treatment of AIDS disease
• Vinka alkaloids used in the treatment of various cancers
• A Vitamin
• Diabetes drugs such as chlorpropamide, glibenclamide, glipizide or tolbutamide
• Water tablets, such as hydrochlorothiazide, used to treat fluid retention and high blood pressure

• Phenytoin used to control the palace, carbamazepine
• Antibiotics for infections such as rifampicin or rifabutin
• Cyclosporine or tacrolimus to prevent transfer rejection
• Theophylline used to control asthma
• Zidovudine, also known as AZT, used in patients infected with the Human Immunodeficiency Virus (HIV)
• Halofantrin
Please inform your doctor or pharmacist if you are using or have recently used any medicine with or without a prescription.

3. How to use TRIFLUCAN?
Instructions for proper use and dose / application frequency:
Fluconazole should be dependent on the sex and seriousness of the daily dose of fungus infection. In cases of infection requiring treatment with recurrent doses, the treatment should continue until clinical parameters or laboratory tests indicate that active fungal infection has passed. An inadequate treatment duration leads to recurrent active infection. To prevent recurrence; AIDS and cryptococcal meningitis should be treated idem.
The following doses may be administered if not otherwise recommended by the physician:

Mucosal canker - the dose depends on the site of infection
50 mg once daily for 7-14 or 14-30 days. Doses are sometimes increased to 100 mg.

Fungal skin infections
50 mg once a day for 2-4 weeks (up to 6 weeks for athlete foot)
Systemic fungal infections
400 mg on the first day, 200-400 mg once a day for 6-8 weeks, or longer if necessary. If you have AIDS, your doctor can use the drug for an indefinite period of time, 200 mg per day, after full primer cure to prevent recurrence.
To prevent your fungal infection from snatching
Once you are infected, you are 50-400mg once a day. If you are at high risk for systemic infection, 400mg once a day. Fluconazole administration should be initiated a few days before the onset in patients with a predicted reduction in fractional cell count (neutropenia) and should continue for 7 more days after the neutrophil count has increased above 1000 / mm3.

Return of an infection originating from Cryptococcus (a kind of fungal infection) Repeatedly 100-200 mg once a day
The immune system is sufficient for patients with developing systemic fungal diseases
The appropriate time for each patient should be selected, with 11-24 months for coccidioidomycosis, 2-17 months for paroxoxidioidomycosis, 1-16 months for sporotrichosis and 3-17 months for histoplasmosis.

Application path and method:
It is taken orally.
Fluconazole is administered either orally or intravenously infused at a rate not exceeding 10 ml per minute. The route of administration depends on the clinical condition of the patient. There is no need to change daily doses while passing from the intravenous route to the oral route or doing the opposite.
Different age groups:
Use in children:
4 weeks to 15 years
mucosal infections
3 mg / kg once daily. 6 mg / kg on the first day.
systemic fungal infections
6-12 mg / kg once a day.
prevention of fungal infections
If there is a risk of infection, 3-12 mg / kg once a day.
3-4 weeks
Same dose as above but given every 2 days.
A maximum of 12 mg / kg of doxycycline every 2 days.
Less than 2 weeks
Same dose as above but given every 3 days.
A maximum of 12 mg / kg of doxycycline every 3 days.
Children should not exceed a maximum dosage of 400 mg daily.

Use in the elderly:
Normal adults will be given if you do not have problems with your kidneys.
Special use cases:
Kidney failure:
A single dose does not require dose adjustment in case of need. Your doctor can change your dose depending on your kidney infection.

Liver failure:
Not available.

If you have an impression that the effect of TRIFLUCAN is too strong or weak, talk to your doctor or pharmacist.

If you use more TRIFLUCAN than you need:
You do not get more than your doctor tells you.
If you use TRIFLUCAN, if you have used too much, talk to a doctor or pharmacist.

If you forget to use TRIFLUCAN:
Do not take double doses to compensate for forgotten doses.
Possible effects of termination of treatment with TRIFLUCAN:
Do not stop taking TRIFLUCAN unless your doctor tells you. Your doctor will determine the best method for you when you need to stop taking TRIFLUCAN. If you have any problems with using TRIFLUCAN, consult your doctor.

4. What are the possible side effects?
Like all medicines, there may be side effects in people sensitive to substances in the contents of TRIFLUCAN.
Serious allergic reactions are rare, but several people have allergic reactions. If you experience any of the following symptoms, tell your doctor immediately:
• Sudden wheezing, difficulty in breathing or choking
• Swelling on eyelids, face or lips
• itching, skin red or itchy red stains on the whole body
• Skin rash
• Severe skin reactions such as rash that may cause wrinkling (may also affect mouth and tongue).
• If you have AIDS, you are more likely to show severe skin reactions to medications, including TRIFLUCAN.
The side effects are listed as shown in the following categories.
Very common: at least 1 index of 10 patients can be seen.
Common: fewer than 10 patients, but more than 100 patients.
Uncommon: less than one in 100 patients, but more than one in 1000 patients.
Rare: 1,000 cases can be seen in less than one patient.
Very rare: 10,000 can be seen in less than one patient.
Unknown: Can not be predicted by moving from the available data.
Common:
• Headache
• Abdominal pain
• Nausea
• Vomiting
• Midee inconvenience
• Diarrhea
• Gas
• Rash
• High alkaline phosphatase levels
• Increase in aspartate aminotransferase
• Increase in blood alkaline phosphatase
Unusual:
• Insomnia
• Sleepiness
• Seizures
• Drowsiness
• Consensus
• Taste disorder
• Dizziness due to impaired balance (vertigo)
• Indigestion, digestive disorders
• Gas and mouth installation
• slowing or stopping the ballast flow
• Jaundice
• Increased awareness
• Itching
• Hives
• Increase in perpetuity
• Muscle aches
• Fatigue
• Unsatisfaction
• Falling hard
• Fire
Rare:
• Reduction in the number of white blood cells
• Decrease in white blood cell count
• Decrease in number of adjacent cells
• Decrease in platelet-blood pulse rate
• Very severe response of the body to allergenic substances, sudden hypersensitivity (including allergy-ending face and throat swelling, face edema, pruritus, rash)
• High cholesterol
• High triglyceride
• Elevation of blood potassium level above normal

• Flicker
• QT extension
• Life-threatening irregular heart rhythms (torsade de pointes)
• Toxicity to the liver, which rarely results in death
• Liver failure
• Liver inflammation
• Jaundice
• Death or damage to tissues of liver cells or affecting liver cells
• Severe disease (toxic epidermal necrolysis) with droplet-filled bubbles in the deep
• Inflammation (Stevens-Johnson syndrome) with blood and skin around the eyes and swelling and redness
• Acute diffuse exanthematous pustulosis exfoliative skin diseases
• Percentage edema
• Hair loss
Pediatric patients
The incidence and pattern of adverse events recorded during pediatric clinical trials and laboratory abnormalities are comparable to those seen in adults.
If you encounter any side effects not mentioned in these instructions for use, please inform your doctor or pharmacist.

5. Keeping TRIFLUCAN.
Store TRIFLUCAN in places where children can not, can not reach, and in their packaging.
Store at room temperature below 30 ° C.
Use in accordance with the expiration date.